I just wanted to pass along the news that the Seedi project has released a beta version for Windows. It was designed around CD games but they also included support for the Retrode which will auto launch your games as soon as you insert a cartridge. I tried this out tonight with Indy's Greatest Adventures and it worked like a charm. You will have to edit the configuration inside Mednafen to get your controllers or scanlines working, but it seems fairly functional based on my initial testing.
https://seedisystem.com/seedi-windows-beta/